Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming
M. von Joest, C. Chen, T. Douche, A. Chiche, M. Matondo, H. Li
This study shows that senescence promotes reprogramming through the SASP factor Amphiregulin, which enhances proliferation and MET via EGFR signaling, improving reprogramming efficiency.
bioRxiv · Sep 1, 2021 · PreprintCell Biology