BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology
M. Taga, V. A. Petyuk, C. White, G. Marsh, Y. Ma, H.-U. Klein, S. M. Connor, A. Khairallah, M. Olah, J. Schneider, R. Ransohoff, D. A. Bennett, A. Crotti, E. M. Bradshaw, P. L. De Jager
The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.
bioRxiv · Jan 31, 2019Cell Biology