Author

P. L. De Jager

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

D. A. Bennett· 3 shared E. M. Bradshaw· 2 shared H.-U. Klein· 2 shared V. A. Petyuk· 2 shared A. Crotti· 1 shared A. Khairallah· 1 shared A. Kroshilina· 1 shared A. Lee· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

D. A. Bennett

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases

T. Roostaei, C. Diaconu, H. Touil, C. Harbison, Y. Zhang, S. Epstein, J. Tuddenham, K. Thakur, J. Bryois, H. Wiendl, G. Meyer zu Hörste, D. Malhotra, C. Riley, V. Menon, P. L. De Jager

This study uses scRNA-seq to define immune cell communities in CSF of MS and other neuroinflammatory diseases, identifying changes in cell types and potential therapeutic targets.

bioRxiv · Nov 1, 2021 · PreprintImmunology

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

C. Trumpff, E. Owusu-Ansah, H.-U. Klein, A. Lee, V. Petyuk, T. S. Wingo, A. Wingo, M. Thambisetty, L. Ferrucci, N. Seyfried, D. A. Bennett, P. L. De Jager, M. Picard

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

bioRxiv · Jul 19, 2021Cell Biology

Enhancing top-down proteomics of brain tissue with FAIMS

J. M. Fulcher, A. Makaju, R. J. Moore, M. Zhou, D. C. Bennett, P. L. De Jager, W.-J. Qian, L. Pasa-Tolic, V. A. Petyuk

This study shows that adding FAIMS to top-down proteomics improves proteome coverage in Alzheimer's brain tissue by doubling the number of non-redundant proteoforms identified.

bioRxiv · Jan 18, 2021Biochemistry

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

K. Borkowski, A. Y. Taha, T. L. Pedersen, P. L. De Jager, D. A. Bennett, R. Kaddurah-Daouk, J. W. Newman

bioRxiv · Sep 3, 2020Pathology

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

C. Park, G. Ponath, M. Levine-Ritterman, E. Bull, E. C. Swanson, P. L. De Jager, B. M. Segal, D. Pitt

This study identifies distinct myeloid and astrocyte phenotypes in MS lesions using imaging mass cytometry and shows their spatial distribution and interactions.

bioRxiv · Jun 23, 2019Immunology

A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System

C. Ruan, L. Sun, A. Kroshilina, L. Beckers, P. L. De Jager, E. M. Bradshaw, S. Hasson, G. Wang, W. Elyaman

This paper introduces a Tmem119-tdTomato reporter mouse model to specifically study microglia in the CNS, showing tdTomato+ cells are microglia-specific and detectable in health and disease.

bioRxiv · Jun 10, 2019Immunology

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

M. Taga, V. A. Petyuk, C. White, G. Marsh, Y. Ma, H.-U. Klein, S. M. Connor, A. Khairallah, M. Olah, J. Schneider, R. Ransohoff, D. A. Bennett, A. Crotti, E. M. Bradshaw, P. L. De Jager

The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.

bioRxiv · Jan 31, 2019Cell Biology