Author

D. A. Bennett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Animal Behavior & Cognition· 1 Biochemistry· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 7 Research Focus:cell type annotation· 6 Organism:human· 6 Approach:statistical model· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

H.-U. Klein· 4 shared P. L. De Jager· 3 shared A. Wingo· 2 shared C. Trumpff· 2 shared L. Ferrucci· 2 shared M. Picard· 2 shared M. Thambisetty· 2 shared N. Seyfried· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

H.-U. Klein

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.

Y. C. M. Penalva, S. Paschkowsky, J. Yang, S. J. Recinto, J. Cinkorpumin, M. Ruelas Hernandez, B. Xiao, A. Nitu, H. Y.-L. Wu, H. M. Munter, B. Michalski, M. Fahnestock, W. A. Pastor, D. A. Bennett, L. M. Munter

This study shows that loss of RHBDL4 in Alzheimer's disease mice increases APP and rescues cognition by reducing proteasomal degradation of β-catenin.

bioRxiv · Feb 22, 2024Animal Behavior & Cognition

Psychosocial experiences are associated with human brain mitochondrial biology

C. Trumpff, A. Monzel, C. Sandi, V. Menon, H.-U. Klein, M. Fujita, A. J. Lee, V. A. Petyuk, C. Hurst, D. A. Duong, N. Seyfried, A. Wingo, T. S. Wingo, Y. Wang, M. Thambisetty, , M. Picard

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

bioRxiv · Oct 6, 2023Cell Biology

Tissue- and sex-specific DNA damage tracks aging in rodents and humans

A. Guilbaud, F. Ghanegolmohammadi, Y. Wang, J. Leng, A. Kreymerman, J. Gamboa Varela, J. Garbern, H. Elwell, F. Cao, E. M. Ricci-Blair, C. Liang, S. Balamkundu, C. Vidoudez, M. S. DeMott, K. Bedi, , P. C. Dedon

This study identifies DNA damage patterns across tissues and sexes in rodents and humans, revealing age- and sex-dependent variations in DNA adducts and their potential as disease markers.

bioRxiv · Nov 28, 2022 · PreprintBiochemistry

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

A. M. Obeidat, M. J. Wood, S. Ishihara, J. Li, L. Wang, D. Ren, D. A. Bennett, R. J. Miller, A.-M. Malfait, R. E. Miller

This study shows that Piezo2 is essential for mechanical pain sensitization in osteoarthritis, as Piezo2-deficient mice are protected from mechanical hypersensitivity in two models.

bioRxiv · Mar 12, 2022Physiology

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

C. Trumpff, E. Owusu-Ansah, H.-U. Klein, A. Lee, V. Petyuk, T. S. Wingo, A. Wingo, M. Thambisetty, L. Ferrucci, N. Seyfried, D. A. Bennett, P. L. De Jager, M. Picard

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

bioRxiv · Jul 19, 2021Cell Biology

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

K. Borkowski, A. Y. Taha, T. L. Pedersen, P. L. De Jager, D. A. Bennett, R. Kaddurah-Daouk, J. W. Newman

bioRxiv · Sep 3, 2020Pathology

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

M. Taga, V. A. Petyuk, C. White, G. Marsh, Y. Ma, H.-U. Klein, S. M. Connor, A. Khairallah, M. Olah, J. Schneider, R. Ransohoff, D. A. Bennett, A. Crotti, E. M. Bradshaw, P. L. De Jager

The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.

bioRxiv · Jan 31, 2019Cell Biology

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

P. De Jager, Y. Ma, C. McCabe, J. Xu, B. N. Vardarajan, D. Felsky, H.-U. Klein, C. C. White, M. A. Peters, B. Lodgson, P. Nejad, A. Tang, L. M. Mangravite, L. Yu, C. Gaiteri, , D. A. Bennett

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

bioRxiv · Jan 23, 2018Cell Biology