MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS
P. Iyer, B. Zhang, T. Liu, M. Jin, K. Hart, J. Zhang, J. Song, W. C. Chan, T. Siddiqi, S. T. Rosen, A. Danilov, L. Wang
This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.
bioRxiv · Feb 7, 2023 · PreprintCancer Biology