Author

K. Hart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

L. Wang· 2 shared A. Danilov· 1 shared A. I. Ivanov· 1 shared B. Zhang· 1 shared C. Fiocchi· 1 shared C. Park· 1 shared C. Rayan· 1 shared D. Czarnecki· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

L. Wang

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Author profile →

3 papers

Recent·Most cited

Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis

M. Fernandez, Q. Jia, L. Yu, X. Wang, K. Hart, Z. Jia, R.-J. Lin, L. Wang

This paper develops PRECIS, a method combining prime editing and a synthetic intron reporter to efficiently generate SF3B1 mutant cell lines that recapitulate cancer-related splicing and CNV events.

bioRxiv · Feb 23, 2024 · PreprintCancer Biology

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

P. K. Mukherjee, Q. T. Nguyen, J. Li, S. Zhao, S. M. Christensen, G. A. West, J. Chandra, I. O. Gordon, S. Lin, J. Wang, R. Mao, D. Czarnecki, C. Rayan, P. Kotak, T. Plesec, , F. Rieder

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

bioRxiv · Apr 3, 2023Immunology

MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS

P. Iyer, B. Zhang, T. Liu, M. Jin, K. Hart, J. Zhang, J. Song, W. C. Chan, T. Siddiqi, S. T. Rosen, A. Danilov, L. Wang

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

bioRxiv · Feb 7, 2023 · PreprintCancer Biology