Author

W. C. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Song· 2 shared A. Danilov· 1 shared B. Zhang· 1 shared D. Fonseca-Arce· 1 shared D. Khanduja· 1 shared E. Leveille· 1 shared G. Xiao· 1 shared H. Jumaa· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

J. Song

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Author profile →

2 papers

Recent·Most cited

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

K. N. Cosgun, H. Jumaa, M. E. Robinson, X. Liang, G. Xiao, L. N. Chan, J. Lee, K. Kume, E. Leveille, D. Fonseca-Arce, D. Khanduja, H. L. Ng, N. Feldhahn, J. Song, W. C. Chan, , M. Mueschen

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS

P. Iyer, B. Zhang, T. Liu, M. Jin, K. Hart, J. Zhang, J. Song, W. C. Chan, T. Siddiqi, S. T. Rosen, A. Danilov, L. Wang

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

bioRxiv · Feb 7, 2023 · PreprintCancer Biology