Rapid activation of IL-2 receptor signaling by CD301b+DC-derived IL-2 dictates the outcome of helper T cell differentiation
N. Tatsumi, J. El-Fenej, A. Davila-Pagan, Y. Kumamoto
The paper identifies CD301b+ DC-derived IL-2 as a key driver of Th2 differentiation by activating IL-2 receptor signaling in CD4 T cells, while inhibiting T follicular helper fate.
bioRxiv · Oct 26, 2023 · PreprintImmunology