High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism
A. Dumitru, K. R. N. V. Deepak, H. Liu, M. Koehler, C. Zhang, H. Fan, D. Alsteens
This study identifies a cooperative two-site binding mechanism for C5aR activation using atomic force microscopy, steered molecular dynamics, and functional assays.
bioRxiv · Apr 3, 2020 · PreprintBiochemistry