H. Fan

Five-layered robot (F-robot) based on functionally graded multilayer foam antiviral low-carbon (F-MAX) system for Pathogenic Microorganism Elimination

The paper introduces an air filtration system using a multilayer composite with antiviral and antibacterial properties, suitable for both commercial and residential environments.

Overcoming the preferred orientation problem in cryoEM with self-supervised deep-learning

This paper introduces spIsoNet, a deep-learning tool that improves 3D reconstruction isotropy and particle alignment in cryoEM by addressing the preferred orientation problem without altering specimen preparation.

CPT1A Mediates Radiation Sensitivity in Colorectal Cancer

This study identifies CPT1A as a mediator of radiation sensitivity in colorectal cancer, showing its role in ROS scavenging and DNA damage response through the FOXM1-SOD1/SOD2/CAT axis.

Rapid High-Throughput Isolation and purification of Chicken Myoblasts Based on Deterministic Lateral Displacement Microfluidic Chips

This study develops a microfluidic platform for isolating chicken myoblasts using deterministic lateral displacement, achieving 80% recovery and 99% purity.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

This paper shows that GrgA is essential for Chlamydia growth, plasmid maintenance, and differentiation, and identifies its role in regulating sigma factors and gene expression.

Competitive fitness and homologous recombination of SARS-CoV-2 variants of concern

This study examines the competitive fitness and homologous recombination of SARS-CoV-2 variants in vitro, showing cell-specific fitness differences and recombination hotspots.

Requirement of GrgA for Chlamydia infectious progeny production

This study identifies GrgA as essential for Chlamydia's secondary differentiation from reticulate bodies to infectious elementary bodies using a novel gene knockdown strategy.

Measuring chondrocyte viability of articular cartilage based on label-free two-photon microscopy and deep learning image analysis

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

Pathogen-Host Adhesion between SARS-CoV-2 S Proteins from Different Variants and Human ACE2 Probed at Single-Molecule and Single-Cell Levels

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.

Calcium-Mediated Modulation of Blood-Brain Barrier Permeability by Laser Stimulation of Endothelial-Targeted Nanoparticles

This study investigates how laser stimulation of endothelial-targeted nanoparticles increases blood-brain barrier permeability through calcium signaling and cytoskeletal changes.

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

A novel cryo-electron microscopy support film based on 2D crystal of HFBI protein

This paper introduces a new cryo-EM support film using HFBI protein 2D crystals to improve protein structure resolution by reducing preferred orientation and denaturation during vitrification.

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

Acoustic frequency-dependent physical mechanism of sub-MHz ultrasound neurostimulation

This study investigates how different acoustic frequencies affect ultrasound neuromodulation by examining cavitation and radiation forces in cultured rat cortical cells.

The Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

This paper identifies the guanylyltransferase activity in SARS-CoV-2 RNA polymerase and shows remdesivir triphosphate inhibits both GTase and polymerase functions.

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress

This study identifies WWOX as a host protein that interacts with viral PPxY motifs to inhibit virus egress, revealing a competitive interplay with angiomotin.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.