TDP-43 α-helical structure tunes liquid-liquid phase separation and function
A. E. Conicella, G. L. Dignon, G. H. Zerze, H. B. Schmidt, A. M. D'Ordine, Y. C. Kim, R. Rohatgi, Y. M. Ayala, J. Mittal, N. L. Fawzi
This study shows that mutations in TDP-43's helical region modulate its phase separation and function, with implications for ALS and synthetic biology.
bioRxiv · May 18, 2019Biochemistry