Author

A. E. Nichols

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:mouse· 6 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. E. Loiselle· 7 shared A. Korcari· 2 shared E. Adjei-Sowah· 2 shared S. N. Muscat· 2 shared A. Kollar· 1 shared B. Xiao· 1 shared C. Ketonis· 1 shared C. Soto· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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7 shared papersCell Biology

A. E. Loiselle

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Development of a Nanoparticle-Based Tendon-Targeting Drug Delivery System to Pharmacologically Modulate Tendon Healing

E. E. Adjei-Sowah, I. Chandrasiri, B. Xiao, Y. Liu, J. Ackerman, C. Soto, A. E. Nichols, K. Nolan, D. S. W. Benoit, A. E. Loiselle

This paper develops a nanoparticle-based drug delivery system targeting tendons to improve healing by delivering Niclosamide, showing enhanced functional and mechanical outcomes compared to systemic delivery.

bioRxiv · Nov 29, 2023Bioengineering

Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing

J. E. Ackerman, E. Adjei-Sowah, A. Korcari, S. N. Muscat, A. E. Nichols, M. R. Buckley, A. E. Loiselle

The paper identifies Periostin as a critical niche supporting myofibroblast dynamics and fibrosis during tendon healing, suggesting it as a therapeutic target.

bioRxiv · Jul 21, 2023Cell Biology

Epitenon-derived cells comprise a distinct progenitor population that contributes to both fibrosis and regeneration following acute flexor tendon injury in a spatially-dependent manner

A. E. Nichols, L. Benoodt, E. Adjei-Sowah, K. Jerreld, A. Kollar, C. Ketonis, A. E. Loiselle

bioRxiv · Jan 30, 2023 · PreprintCell Biology

CCR2 identifies tendon resident macrophage and T cell populations while CCR2 deficiency impedes late tendon healing

S. Muscat, A. E. Nichols, E. Gira, A. E. Loiselle

This study examines the role of CCR2 in tendon healing by analyzing CCR2GFP/+ and knockout mice, finding that CCR2 deficiency reduces macrophages and impairs healing.

bioRxiv · Jul 20, 2022 · PreprintCell Biology

Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

A. Korcari, A. E. Nichols, A. E. Loiselle

This study shows that depletion of Scleraxis-lineage cells in mice accelerates tendon extracellular matrix aging, revealing distinct functional changes in aged versus DTR tenocytes.

bioRxiv · Jan 20, 2022Cell Biology

Short-Duration RAGE Antagonism Transiently Disrupts Tendon Homeostasis and does not Alter Diabetic Tendon Healing

A. E. Nichols, S. N. Muscat, A. E. Loiselle

This study tests RAGE antagonism's effect on diabetic tendon healing and homeostasis, finding no improvement in healing but transient disruption in control tendons.

bioRxiv · May 11, 2021 · PreprintPathology

Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture

A. E. Nichols, S. E. Miller, L. J. Green, M. S. Richards, A. E. Loiselle

This study compares isolation methods for tendon cells in vitro, finding that explant methods reduce proliferative capacity and alter lineage composition compared to digestion methods.

bioRxiv · Mar 7, 2021Cell Biology