MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α
V. Kovaleva, L.-Y. Yu, L. Ivanova, J. Nam, A. Eesmaa, E.-P. Kumpula, J. Huiskonen, P. Lindholm, M. H. Voutilainen, M. Karelson, M. Saarma
This study identifies MANF's mechanism of action through its interaction with IRE1α, showing it modulates UPR and protects neurons from ER stress.
bioRxiv · Sep 22, 2020 · PreprintCell Biology