Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
C. M. Driggers, Y.-Y. Kuo, P. Zhu, A. ElSheikh, S.-L. Shyng
This study reports the cryoEM structure of an open KATP channel with PIP2 bound, revealing two PIP2 binding sites and their role in channel regulation and neonatal diabetes.
bioRxiv · Aug 1, 2023 · PreprintBiochemistry