G. Bou-Gharios

This study shows that bile excretes homogentisic acid in alkaptonuria mice, both on and off nitisinone treatment, revealing a new pathway for metabolite elimination.

This study identifies the ligandome of LRP1 in cartilage using a top-down approach, revealing novel ligands and their role in osteoarthritis.

This study examines structural, cellular, and viscoelastic changes in the ACL of a murine PTOA model, finding ECM modifications and altered biomechanics.

This study shows that expressing LaNt 31 during mouse development causes tissue-specific defects and basement membrane disruption, supporting a model of laminin self-regulation.

This study shows that homotrimeric collagen-1 in oim heterozygotes alleviates the mutant allele's effect, but genetic interaction causes bone fragility in oim homozygotes.

This study investigates the metabolic consequences of HGD deficiency in alkaptonuria, revealing new roles for phase I and II biotransformations in detoxifying endogenous metabolites.

This study shows that deleting CCN2 in adult chondrocytes does not alter the development of post-traumatic osteoarthritis in mice.

This study shows that Syndecan-3 promotes bone formation by enhancing WNT signaling in osteoblasts, and its absence leads to osteoporosis-like features in mice.

This study examines meniscal and ligament changes in two mouse OA models, finding increased mineralisation and chondrogenesis associated with cartilage degeneration.