Author

S.-L. Shyng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 6 Research Focus:protein structure prediction· 6 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Yoshioka· 3 shared G. M. Martin· 3 shared M. W. Sung· 3 shared Z. Yang· 3 shared B. Kandasamy· 2 shared B. L. Patton· 2 shared B. Mostofian· 2 shared C. M. Driggers· 2 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

C. Yoshioka

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Author profile →

7 papers

Recent·Most cited

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

C. M. Driggers, Y.-Y. Kuo, P. Zhu, A. ElSheikh, S.-L. Shyng

This study reports the cryoEM structure of an open KATP channel with PIP2 bound, revealing two PIP2 binding sites and their role in channel regulation and neonatal diabetes.

bioRxiv · Aug 1, 2023 · PreprintBiochemistry

Ligand-mediated structural dynamics of a mammalian pancreatic KATP channel

M. W. Sung, C. M. Driggers, B. Mostofian, J. D. Russo, B. L. Patton, D. M. Zuckerman, S.-L. Shyng

The paper investigates how ligands affect the structural dynamics of pancreatic KATP channels using cryo-EM and molecular dynamics simulations.

bioRxiv · Mar 2, 2022Biochemistry

Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides

M. W. Sung, Z. Yang, B. L. Patton, B. Mostofian, J. Russo, D. M. Zuckerman, S.-L. Shyng

The paper determines cryoEM structures of vascular KATP channels bound to Mg-nucleotides and reveals a conformational pathway for activation.

bioRxiv · May 15, 2021Biochemistry

AKAP79/150 coordinates leptin-induced PKA activation to regulate KATP channel trafficking in pancreatic β-cells

V. Cochrane, Z. Yang, M. Dell'Acqua, S.-L. Shyng

This study shows leptin activates PKA via AKAP79/150 to increase KATP channel surface trafficking in β-cells, affecting insulin secretion.

bioRxiv · Nov 25, 2020Cell Biology

Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM

G. M. Martin, M. W. Sung, Z. Yang, L. M. Innes, B. Kandasamy, L. David, C. Yoshioka, S.-L. Shyng

This study reveals how pharmacochaperones stabilize KATP channels by binding to SUR1 and supporting Kir6.2 N-terminus insertion, enabling mutant channel assembly.

bioRxiv · Mar 8, 2019 · PreprintBiophysics

Anti-diabetic drug binding site in KATP channels revealed by Cryo-EM

G. M. Martin, B. Kandasamy, F. DiMaio, C. Yoshioka, S.-L. Shyng

The paper presents a cryo-EM structure of KATP channels bound to glibenclamide and ATP, revealing the drug's binding site and its interaction with the channel.

bioRxiv · Aug 5, 2017Biochemistry

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

G. M. Martin, C. Yoshioka, E. A. Rex, J. F. Fay, Q. Xie, M. R. Whorton, J. Z. Chen, S.-L. Shyng

The paper presents a cryo-EM structure of the KATP channel, revealing assembly and gating mechanisms involving SUR1 and Kir6.2 interactions with ATP and PIP2.

bioRxiv · Dec 16, 2016Biochemistry