Tumour suppressor WT1 regulates the let-7-Igf1r axis in kidney mesenchyme
R. Bharathavikru, J. Slight, S. Aitken, G. Petrovich, J. Charlton, V. Stancheva, A. Essafi, K. Pritchard Jones, N. Hastie
The paper shows that WT1 regulates the let-7-Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling disruption.
bioRxiv · Oct 30, 2019 · PreprintCancer Biology