Author

S. Aitken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1

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Research Focus:cancer & tumor microenvironment· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

A. Ewing· 2 shared C. A. Semple· 2 shared A. D. Yates· 1 shared A. Essafi· 1 shared A. Hamdan· 1 shared A. Khamseh· 1 shared A. M. Redmond· 1 shared A. Matakidou· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

A. Ewing

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Author profile →

5 papers

Recent·Most cited

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

A. Ewing, A. Meynert, R. Silk, S. Aitken, D. P. Bendixsen, M. Churchman, S. L. Brown, A. Hamdan, J. Mattocks, G. R. Grimes, T. Ballinger, R. L. Hollis, C. S. Herrington, J. P. Thomson, K. Sherwood, , C. A. Semple

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

bioRxiv · Jan 12, 2024Cancer Biology

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

C. T. Davidson, E. Miller, M. Muir, J. C. Dawson, M. Lee, S. Aitken, A. Serrels, S. P. Webster, N. Z. M. Homer, R. Andrew, V. G. Brunton, P. W. F. Hadoke, B. R. Walker

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

bioRxiv · Aug 4, 2021 · PreprintCancer Biology

Pervasive lesion segregation shapes cancer genome evolution

S. J. Aitken, C. J. Anderson, F. Connor, O. Pich, V. Sundaram, C. Feig, T. F. Rayner, M. Lukk, S. Aitken, J. Luft, E. Kentepozidou, C. Arnedo-Pac, S. Beentjes, S. E. Davies, R. M. Drews, , M. S. Taylor

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

bioRxiv · Dec 8, 2019Cancer Biology

Tumour suppressor WT1 regulates the let-7-Igf1r axis in kidney mesenchyme

R. Bharathavikru, J. Slight, S. Aitken, G. Petrovich, J. Charlton, V. Stancheva, A. Essafi, K. Pritchard Jones, N. Hastie

The paper shows that WT1 regulates the let-7-Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling disruption.

bioRxiv · Oct 30, 2019 · PreprintCancer Biology

Modularity of genes involved in local adaptation to climate despite physical linkage

K. Lotterhos, S. Yeaman, J. Degner, S. Aitken, K. Hodgins

The paper introduces co-association network analysis to study genetic modularity in lodgepole pine's adaptation to climate, finding support for modular architectures but not increased recombination.

bioRxiv · May 17, 2018Evolutionary Biology