The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles
R. T. Ormsby, K. Hosaka, A. Evdokiou, A. Odysseos, D. M. Findlay, L. B. Solomon, G. J. Atkins
This study examines how vitamin E analogues α-tocopherol and γ-tocotrienol affect human osteocyte gene expression and mineralisation in response to UHMWPE wear particles, finding they reduce RANKL:OPG ratio but may promote osteolysis.
bioRxiv · Apr 17, 2022Cell Biology