Author

L. B. Solomon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

G. J. Atkins· 7 shared A. R. Zelmer· 4 shared D. Yang· 4 shared N. J. Gunn· 3 shared D. M. Findlay· 2 shared D. Muratovic· 2 shared K. Richter· 2 shared S. P. Kidd· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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7 shared papersMicrobiology

G. J. Atkins

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Beyond the Colony-Forming-Unit: Rapid Bacterial Evaluation in Osteomyelitis

Q. Sun, K. Huynh, D. Muratovic, N. J. Gunn, A. R. Zelmer, L. B. Solomon, G. J. Atkins, D. Yang

This study demonstrates the discrepancy between colony-forming-unit and bacterial genome copy number in osteomyelitis and proposes an improved workflow for bacterial burden quantification in clinical specimens.

eLife · Jun 24, 2024Peer-reviewedMicrobiology

Antibiotics at Clinical Concentrations Show Limited Effectivity Against Acute and Chronic Intracellular S. aureus Infections in Osteocytes

A. R. Zelmer, D. Yang, N. J. Gunn, L. B. Solomon, R. Nelson, S. P. Kidd, K. Richter, G. J. Atkins

This study evaluates the effectiveness of antibiotics against intracellular S. aureus infections in osteocytes, finding limited efficacy even at high concentrations.

bioRxiv · Dec 17, 2023 · PreprintMicrobiology

Staphylococcus aureus Persistence in Osteocytes: Weathering the Storm of Antibiotics and Autophagy/Xenophagy

N. J. Gunn, A. R. Zelmer, S. P. Kidd, L. B. Solomon, D. Yang, E. Roscioli, G. J. Atkins

This study investigates how antibiotics and autophagy modulation affect intracellular Staphylococcus aureus persistence in osteocytes, finding that antibiotics inhibit autophagy but do not clear bacterial DNA.

bioRxiv · Oct 27, 2023 · PreprintMicrobiology

Culture of Saos-2 cells under hypoxic conditions stimulates rapid differentiation to an osteocyte-like stage

A. R. Zelmer, Y. Starczak, L. B. Solomon, K. Richter, D. Yang, G. J. Atkins

This study shows that culturing Saos-2 cells under hypoxic conditions accelerates their differentiation into osteocyte-like cells within 14 days.

bioRxiv · Apr 23, 2023 · PreprintCell Biology

Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography

D. Muratovic, D. M. Findlay, M. J. Quinn, R. D. Quarrington, L. B. Solomon, G. J. Atkins

This study compares subchondral bone microstructure and cellular features in hip and knee osteoarthritis, finding distinct differences in bone and osteocyte characteristics between the two joints.

bioRxiv · Jan 18, 2023Pathology

The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles

R. T. Ormsby, K. Hosaka, A. Evdokiou, A. Odysseos, D. M. Findlay, L. B. Solomon, G. J. Atkins

This study examines how vitamin E analogues α-tocopherol and γ-tocotrienol affect human osteocyte gene expression and mineralisation in response to UHMWPE wear particles, finding they reduce RANKL:OPG ratio but may promote osteolysis.

bioRxiv · Apr 17, 2022Cell Biology

Relationships between the Bone Expression of Alzheimer Disease-Related Genes, Bone Remodelling Genes and Cortical Bone Structure in Neck of Femur Fracture

C. J. M. Stapledon, R. Stamenkov, R. Cappai, J. M. Clark, A. Bourke, L. B. Solomon, G. J. Atkins

This study examines the relationship between Alzheimer's disease-related genes and bone structure in patients with femur fractures, finding correlations between gene expression and bone remodeling parameters.

bioRxiv · Nov 2, 2020Physiology