G. J. Atkins

Beyond the Colony-Forming-Unit: Rapid Bacterial Evaluation in Osteomyelitis

This study demonstrates the discrepancy between colony-forming-unit and bacterial genome copy number in osteomyelitis and proposes an improved workflow for bacterial burden quantification in clinical specimens.

Antibiotics at Clinical Concentrations Show Limited Effectivity Against Acute and Chronic Intracellular S. aureus Infections in Osteocytes

This study evaluates the effectiveness of antibiotics against intracellular S. aureus infections in osteocytes, finding limited efficacy even at high concentrations.

Staphylococcus aureus Persistence in Osteocytes: Weathering the Storm of Antibiotics and Autophagy/Xenophagy

This study investigates how antibiotics and autophagy modulation affect intracellular Staphylococcus aureus persistence in osteocytes, finding that antibiotics inhibit autophagy but do not clear bacterial DNA.

Culture of Saos-2 cells under hypoxic conditions stimulates rapid differentiation to an osteocyte-like stage

This study shows that culturing Saos-2 cells under hypoxic conditions accelerates their differentiation into osteocyte-like cells within 14 days.

Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography

This study compares subchondral bone microstructure and cellular features in hip and knee osteoarthritis, finding distinct differences in bone and osteocyte characteristics between the two joints.

Elevated levels of active Transforming Growth Factor β1 in the subchondral bone relate spatially to cartilage loss and impaired bone quality in human knee osteoarthritis

This study shows that higher active TGFβ1 levels in human subchondral bone correlate with cartilage loss and poor bone quality in knee OA.

The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles

This study examines how vitamin E analogues α-tocopherol and γ-tocotrienol affect human osteocyte gene expression and mineralisation in response to UHMWPE wear particles, finding they reduce RANKL:OPG ratio but may promote osteolysis.

Generation of two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic Differentiation

The paper develops two mesenchymal progenitor cell lines that can differentiate into osteogenic, adipogenic, and chondrogenic lineages and mimic in vivo responses of key regulatory genes.

Relationships between the Bone Expression of Alzheimer Disease-Related Genes, Bone Remodelling Genes and Cortical Bone Structure in Neck of Femur Fracture

This study examines the relationship between Alzheimer's disease-related genes and bone structure in patients with femur fractures, finding correlations between gene expression and bone remodeling parameters.

Sclerostin directly stimulates osteocyte synthesis of fibroblast growth factor-23

This study shows sclerostin directly increases FGF23 production in osteocytes, contributing to phosphate homeostasis regulation.