Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
T. R. Wiche Salinas, Y. Zhang, D. Sarnello, A. Zhyvoloup, L. Raymond-Marchand, D. Planas, M. Lodha, D. Chatterjee, K. Karwacz, S. Oxenford, J.-P. Routy, H. Amrine-Madsen, P. Ancuta, A. Fassati
This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.
bioRxiv · Mar 27, 2021Microbiology