Author

J.-P. Routy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 9 Assay:bulk RNA-seq· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:clustering· 1

Frequent Co-Authors

P. Ancuta· 6 shared C. Tremblay· 4 shared T. R. Wiche Salinas· 4 shared Y. Zhang· 3 shared A. Fert· 2 shared A. Gosselin· 2 shared C. Chartrand-Lefebvre· 2 shared D. Chatterjee· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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6 shared papersImmunology

P. Ancuta

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral Release

A. Fert, J. Richard, L. Raymond Marchand, D. Planas, J.-P. Routy, N. Chomont, A. Finzi, P. Ancuta

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

bioRxiv · Feb 15, 2024 · PreprintImmunology

A Blood Immunological Signature of Subclinical Coronary Artery Atherosclerosis in People Living with HIV-1 Receiving Antiretroviral Therapy

T. R. Wiche Salinas, Y. Zhang, A. Gosselin, N. Fonseca Do Rosario, M. El-Far, A. Filali-Mouhim, J.-P. Routy, C. Chartrand-Lefebvre, A. L. Landay, M. Durand, C. Tremblay, P. Ancuta

This study identifies immunological markers associated with subclinical coronary artery atherosclerosis in HIV+ individuals on ART, finding reduced Th17/Treg ratios and increased non-classical monocyte frequencies correlate with atherosclerosis burden.

bioRxiv · Dec 15, 2023 · PreprintImmunology

Retinoic Acid Boosts HIV-1 Replication in Macrophages via CCR5/SAMHD1-Dependent and mTOR-Modulated Mechanisms

J. Dias, A. Cattin, J.-P. Goulet, L. Raymond Marchand, A. Fert, T. R. Wiche Salinas, C.-D. Ngassaki Yoka, E. Moreira Gabriel, E. R. Caballero, J.-P. Routy, P. Ancuta

This study shows retinoic acid enhances R5 HIV-1 replication in macrophages through CCR5/SAMHD1 and mTOR pathways.

bioRxiv · Oct 5, 2023 · PreprintImmunology

Identification of Aryl Hydrocarbon Receptor as a Barrier to HIV-1 Infection and Outgrowth in CD4+ T-Cells

D. Chatterjee, Y. Zhang, T. R. Wiche Salinas, C.-D. Ngassaki-Yoka, H. Chen, Y. Smail, J.-P. Goulet, B. Bell, J.-P. Routy, P. Ancuta

This study identifies AhR as a barrier to HIV-1 infection and outgrowth in Th17-polarized CD4+ T-cells and suggests AhR inhibitors could enhance viral outgrowth in HIV-1 cure strategies.

bioRxiv · Oct 17, 2022Immunology

Subclinical Atherosclerosis is Associated with Discrepancies in BAFF and APRIL Levels and Altered Breg Potential of Precursor-like Marginal Zone B-Cells in HIV Treated Individuals

M. Naegele Aranguren, K. Doyon-Laliberte, M. El-Far, C. Chartrand-Lefebvre, J.-P. Routy, J.-G. Baril, B. Trottier, C. Tremblay, M. Durand, J. Poudrier, M. Roger

The paper investigates the association between BAFF and APRIL levels and subclinical atherosclerosis in HIV-treated individuals, finding elevated BAFF correlates with CVD risk factors while APRIL shows inverse correlations.

bioRxiv · Aug 26, 2022Immunology

Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection

K. Doyon-Laliberte, M. Aranguren, M. Byrns, J. Chagnon-Choquet, M. Paniconi, J.-P. Routy, C. Tremblay, M.-C. Quintal, N. Brassard, D. E. Kaufmann, J. Poudrier, M. Roger

This study shows that excess BAFF reduces Breg function and NR4A expression in MZp B-cells from HIV-infected individuals, which may impair immune surveillance.

bioRxiv · Aug 15, 2022Immunology

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

E. Brunet-Ratnasingham, A. Morou, M. Dube, J. Niessl, A. E. Baxter, O. Tastet, N. Brassard, G. Ortega-Delgado, R. Charlebois, G. J. Freeman, C. Tremblay, J.-P. Routy, D. E. Kaufmann

bioRxiv · Sep 23, 2021Immunology

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

T. R. Wiche Salinas, Y. Zhang, D. Sarnello, A. Zhyvoloup, L. Raymond-Marchand, D. Planas, M. Lodha, D. Chatterjee, K. Karwacz, S. Oxenford, J.-P. Routy, H. Amrine-Madsen, P. Ancuta, A. Fassati

This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.

bioRxiv · Mar 27, 2021Microbiology

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in patients receiving antiretroviral therapy: a study from Provir/Latitude45 project.

p. recordon pinson, c. tumiotto, p. bellecave, f. salin, p. thebault, a. gosselin, p. ancuta, m. soares, j.-p. routy, h. fleury

The paper compares HIV-1 proviral DNA sequences in blood and gut-associated lymphoid tissue in ART-treated patients, finding low intra-patient divergence and similar CTL epitope profiles between compartments.

bioRxiv · May 5, 2020Microbiology