Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein
E. Bayart, A. Flacco, O. Delmas, L. Pommarel, D. Levy, M. Cavallone, F. Megnin-Chanet, E. Deutsch, V. Malka
This study shows that ultra-short laser-accelerated proton pulses can increase cancer cell mortality in radioresistant cells when PARP1 function is intact.
bioRxiv · Mar 8, 2019Cancer Biology