Cingulin unfolds ZO-1 and organizes myosin-2B and gamma-actin to mechanoregulate apical and tight junction membranes
E. Vasileva, F. Rouaud, D. Spadaro, W. Huang, A. Colom, A. Flinois, J. Shah, V. Dugina, C. Chaponnier, S. Sluysmans, I. Mean, L. Jond, A. Roux, J. Yan, S. Citi
This study shows cingulin regulates apical and tight junction membrane mechanics by organizing myosin-2B and gamma-actin and modulating ZO-1 conformation in MDCK cells.
bioRxiv · May 14, 2020 · PreprintCell Biology