Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver
C. P. Schneider, L. Peng, S. Yuen, M. Chang, R. Karapetyan, E. Nyangau, H. Mohammed, H. Palacios, N. Ziari, L. K. Joe, A. Frakes, A. Dillin, M. K. Hellerstein
This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.
bioRxiv · Oct 29, 2020 · PreprintPhysiology