C. P. Schneider

Aging alters the metabolic flux signature of the ER unfolded protein response in vivo in mice

This study shows that aging in mice leads to an exaggerated and less effective endoplasmic reticulum unfolded protein response (UPRER) under stress, with altered metabolic flux patterns in protein synthesis and lipid production.

Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver

This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.