M. Chang

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Ras Activation by Hydrostatic Pressure is Enhanced by GAP and GEF in vitro

This study investigates how hydrostatic pressure activates Ras in vitro and shows that GAP and GEF domains enhance this activation.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Detecting altered hepatic lipid oxidation by MRI in an animal model of NAFLD

This study develops an MRI-based method to detect altered hepatic lipid oxidation in a NAFLD mouse model, showing decreased β-oxidation efficiency as a potential prognostic indicator.

Unrecognized Potent Activities of Colistin Against Clinically Important mcr+ Enterobacteriaceae Revealed in Synergy with Host Immunity

This study reveals that colistin has previously unrecognized bactericidal activity against mcr-1+ Gram-negative bacteria in physiologic conditions and synergizes with host immunity.

Self-regulation of PIN1-driven auxin transport by cell surface-based auxin signaling in Arabidopsis

The paper identifies a cell surface-triggered auxin signaling mechanism that regulates PIN1-mediated auxin efflux and developmental patterning in Arabidopsis.

Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

The paper introduces Meso-OPM, a microscopy technique that enables large-scale 4D cellular resolution imaging of zebrafish larvae with improved axial resolution and field of view.

A Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

The paper characterizes a substrate-triggered μ-peroxodiiron(III) intermediate in the enzyme BesC, showing it initiates oxidative fragmentation by abstracting hydrogen from C4 and allowing substrate dissociation.

Transmembrane Kinases are essential for plant development

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

Identification of gene products involved in plant colonization by Pantoea sp. YR343 using a diguanylate cyclase expressed in the presence of plants

This study identifies gene products in Pantoea sp. YR343 involved in plant root colonization by analyzing diguanylate cyclases and their downstream effectors.

Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver

This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.

COPII Sec23 proteins form isoform-specific ER exit sites with differential effects on polarized growth

The paper investigates the functional diversity of Sec23/24 isoforms in moss, showing differential roles in ER exit site formation and polarized growth.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Vaping Perpetuates Cardiac Electrical Instability

This study shows that vaping with flavored e-liquids increases cardiac electrical instability in vitro and in vivo, suggesting potential cardiac toxicity.

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

Chondrocyte-specific RUNX2 Overexpression Causes Chondrodysplasia During Development, but is Not Sufficient to Induce OA-like Articular Cartilage Degeneration in Adult Mice Without Injury

This study shows that chondrocyte-specific RUNX2 overexpression during development causes chondrodysplasia but does not induce OA-like cartilage degeneration in adult mice without injury, though it accelerates OA progression after trauma.

F-actin dynamics transform filopodial bridges into intercellular nanotubes capable of distant cell communication

The paper identifies how filopodial bridges transform into intercellular nanotubes through actin dynamics and N-cadherin interactions, enabling long-distance cell communication.