Generation of a SARS-CoV-2 Replicon as a Model System to Dissect Virus Replication and Antiviral Inhibition
X. He, S. Quan, M. Xu, S. Rodriguez, S. L. Goh, J. Wei, A. Fridman, K. A. Koeplinger, S. S. Carroll, J. A. Grobler, A. S. Espeseth, D. B. Olsen, D. J. Hazuda, D. Wang
The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.
bioRxiv · Dec 12, 2020 · PreprintMicrobiology