Author

D. B. Olsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. Young· 2 shared A. Borsellini· 1 shared A. E. Marrouni· 1 shared A. Fridman· 1 shared A. Korkegian· 1 shared A. Madani· 1 shared A. S. Espeseth· 1 shared B. M. Crowley· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

K. Young

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Author profile →

4 papers

Recent·Most cited

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

A. Madani, D. A. Negatu, A. E. Marrouni, R. Miller, C. Boyce, N. Murgolo, C. J. Bungard, M. Zimmerman, V. A. Dartois, M. Gengenbacher, D. B. Olsen, T. Dick

This study evaluates the activity of TPP8, a tricyclic pyrrolopyrimidine gyrase B inhibitor, against Mycobacterium abscessus in vitro, ex vivo, and in vivo.

bioRxiv · May 16, 2022Microbiology

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Generation of a SARS-CoV-2 Replicon as a Model System to Dissect Virus Replication and Antiviral Inhibition

X. He, S. Quan, M. Xu, S. Rodriguez, S. L. Goh, J. Wei, A. Fridman, K. A. Koeplinger, S. S. Carroll, J. A. Grobler, A. S. Espeseth, D. B. Olsen, D. J. Hazuda, D. Wang

The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.

bioRxiv · Dec 12, 2020 · PreprintMicrobiology

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

S. B. Singh, J. Odingo, M. A. Bailey, B. Sunde, A. Korkegian, T. O'Malley, Y. Ovechkina, T. R. Ioerger, J. C. Sacchettini, K. Young, D. B. Olsen, T. Parish

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.

bioRxiv · Mar 10, 2018Microbiology