Author

S. Rodriguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Physiology· 2 Cell Biology· 1 Evolutionary Biology· 1 Paleontology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

D. C. Sarver· 2 shared G. W. Wong· 2 shared J. E. Kirby· 2 shared T. Brennan-Krohn· 2 shared A. B. Green· 1 shared A. E. Jaffe· 1 shared A. Ejarque· 1 shared A. Fridman· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersPhysiology

D. C. Sarver

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: a paradigm shift to virus transmission in South America

G. Tomas, A. Marandino, Y. Panzera, S. Rodriguez, G. d. L. Wallau, F. Dezordi, R. Perez, L. Bassetti, R. Negro, J. Williman, V. Uriarte, F. Grazioli, C. Leizagoyen, S. Riveron, J. Coronel, , R. Perez

The paper identifies clade 2.3.4.4b H5N1 influenza strains in pinnipeds and seabirds in Uruguay, suggesting mammal-to-mammal and seabird transmission routes in South America.

bioRxiv · Dec 14, 2023Microbiology

Activity of Antibiotics against Burkholderia cepacia complex in Artificial Sputum Medium

A. Shukla, S. Rodriguez, T. Brennan-Krohn

This study evaluates antibiotic activity against Bcc in artificial sputum medium, revealing discrepancies between standard susceptibility tests and in vivo-like conditions.

bioRxiv · Dec 13, 2023 · PreprintMicrobiology

Hypermetabolism in mice carrying a near complete human chromosome 21

D. C. Sarver, C. Xu, S. Rodriguez, S. Aja, A. E. Jaffe, F. J. Gao, M. Delannoy, M. Periasamy, Y. Kazuki, M. Oshimura, R. H. Reeves, G. W. Wong

This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.

bioRxiv · Jan 30, 2023Physiology

Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations

W. Barrie, Y. Yang, E. Irving-Pease, K. E. Attfield, G. Scorrano, L. T. Jensen, A. P. Armen, E. A. Dimopoulos, A. Stern, A. Refoyo-Martinez, A. Pearson, A. Ramsoe, C. Gaunitz, F. Demeter, M. L. S. Jorkov, , E. Willerslev

This study identifies the origin of genetic risk variants for multiple sclerosis in Steppe pastoralist populations and traces their spread into Europe through migration.

bioRxiv · Sep 23, 2022Evolutionary Biology

Historical biogeography of Cannabis in the Iberian Peninsula: palynological evidence

V. Rull, F. Burjachs, J. Carrion, A. Ejarque, S. Fernandez, J. A. Lopez-Saez, R. Luelmo-Lautenschlaeger, J. Ochando, S. Perez-Diaz, J. Revelles, S. Riera, S. Rodriguez

This paper uses palynological evidence from nearly 60 Iberian Peninsula sites to analyze the historical spread of Cannabis sativa and its potential links to climate and human activity.

bioRxiv · Sep 16, 2022 · PreprintPaleontology

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

D. Toghani, S. Zeng, E. Mahammadov, E. I. Crosse, N. Seyedhassantehrani, C. Burns, D. Gravano, S. Radtke, H.-P. Kiem, S. Rodriguez, N. Carlesso, A. Pradeep, N. K. Wilson, S. J. Kinston, B. Gottgens, , L. Silberstein

This study identifies Sema4A as a critical niche factor required for myeloid-biased HSC self-renewal and long-term persistence under stress.

bioRxiv · Jan 12, 2022 · PreprintCell Biology

Transcriptomics reveals how minocycline-colistin synergy overcomes antibiotic resistance in multidrug-resistant Klebsiella pneumoniae

T. Brennan-Krohn, A. Grote, S. Rodriguez, J. E. Kirby, A. M. Earl

This paper identifies a synergistic antibiotic combination effective against multidrug-resistant Klebsiella pneumoniae and characterizes its transcriptional mechanisms.

bioRxiv · Sep 21, 2021Microbiology

Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action

K. P. Smith, Y.-S. Kang, A. B. Green, M. G. Dowgiallo, B. C. Miller, L. Chiaraviglio, K. A. Truelson, K. E. Zulauf, S. Rodriguez, R. Manetsch, J. E. Kirby

This paper evaluates the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales, identifying its potent activity and novel mechanism of action involving 16S rRNA helix 34.

bioRxiv · Jun 14, 2021 · PreprintMicrobiology

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

S. Mishra, V. Hahn, N. Sadagopan, B. Dunkerly-Eyring, S. Rodriguez, D. C. Sarver, R. P. Ceddia, S. Murphy, H. Knutsdottir, V. Jani, D. Ashok, C. U. Oeing, B. O'Rourke, K. Sharma, J. Gangoiti, , D. A. Kass

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

bioRxiv · Feb 2, 2021 · PreprintPhysiology

Generation of a SARS-CoV-2 Replicon as a Model System to Dissect Virus Replication and Antiviral Inhibition

X. He, S. Quan, M. Xu, S. Rodriguez, S. L. Goh, J. Wei, A. Fridman, K. A. Koeplinger, S. S. Carroll, J. A. Grobler, A. S. Espeseth, D. B. Olsen, D. J. Hazuda, D. Wang

The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.

bioRxiv · Dec 12, 2020 · PreprintMicrobiology

Genomic characterization of the non-O1/non-O139 Vibrio cholerae strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018

M. Arteaga, J. Velasco, S. Rodriguez, M. Vidal, C. Arellano, F. Silva, L. J. Carreno, R. M. Vidal, D. A. Montero

The paper characterizes a non-O1/non-O139 Vibrio cholerae outbreak strain in Chile, finding it lacks classical virulence genes but carries virulence-associated genomic islands.

bioRxiv · Feb 20, 2020Microbiology