Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases
P. Mohanty, Rashmi, B. I. Habibullah, A. G S, R. Das
This study shows that deamidation of UBC13 by OspI disrupts native and transient interactions with TRAF6RING, inhibiting their complex formation and downstream NF-κB signaling.
bioRxiv · Jun 13, 2019Biochemistry