Author

P. Mohanty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 4 Organism:human· 3 Assay:protein structure· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

J. Mittal· 4 shared A. Rizuan· 3 shared J. Shenoy· 2 shared N. L. Fawzi· 2 shared R. Das· 2 shared A. A. Hyman· 1 shared A. G S· 1 shared A. GS· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiophysics

J. Mittal

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Author profile →

7 papers

Recent·Most cited

RNA-binding tunes the conformational plasticity and intradomain stability of TDP-43 tandem RNA recognition motifs

B. Ozguney, P. Mohanty, J. Mittal

This study uses molecular dynamics simulations to show RNA-binding stabilizes TDP-43 tandem RRMs and reduces conformational plasticity, preventing pathological aggregation.

bioRxiv · Feb 25, 2024Biophysics

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

X. Yan, D. Kuster, P. Mohanty, J. Nijssen, K. Pombo-Garcia, A. Rizuan, T. M. Franzmann, A. Sergeeva, P. M. dos Passos, L. George, S.-H. Wang, J. Shenoy, H. L. Danielson, A. Honigmann, Y. M. Ayala, , A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

bioRxiv · Jan 23, 2024Cell Biology

Bacterial deamidases modulate ubiquitin structure and dynamics to dysregulate ubiquitin signaling

R. Agrata, P. Mohanty, A. Ravichandran, S. Kumari, N. Varshney, A. GS, K. Chauhan, J. Li, K. Chakrabarti, R. A. Byrd, R. Das

This study shows that deamidation of ubiquitin by bacterial enzymes creates salt bridges that disrupt its structure and dynamics, impairing ubiquitin signaling.

bioRxiv · May 22, 2023 · PreprintBiochemistry

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

P. Mohanty, J. Shenoy, A. Rizuan, J. F. M. Ortiz, N. L. Fawzi, J. Mittal

This study identifies aliphatic residues as critical contributors to TDP-43 C-terminal domain phase separation, expanding the molecular understanding of protein phase separation.

bioRxiv · Nov 10, 2022 · PreprintBiophysics

Zn-dependent structural transition of SOD1 modulates its ability to undergo liquid-liquid phase separation.

B. Das, S. Roychowdhury, P. Mohanty, A. Rizuan, J. Mittal, K. Chattopadhyay

This study shows that Zn-dependent structural changes in SOD1 affect its ability to undergo liquid-liquid phase separation, which may contribute to ALS pathology.

bioRxiv · Feb 20, 2022 · PreprintBiophysics

Functional insights of two MATE transporters from Vibrio fluvialis

P. Mohanty, A. Shah, A. K. Bhardwaj

This study characterizes H- and D-type MATE transporters from Vibrio fluvialis, revealing their substrate specificity, ion dependence, and inhibition by reserpine.

bioRxiv · Jan 2, 2021 · PreprintMicrobiology

Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases

P. Mohanty, Rashmi, B. I. Habibullah, A. G S, R. Das

This study shows that deamidation of UBC13 by OspI disrupts native and transient interactions with TRAF6RING, inhibiting their complex formation and downstream NF-κB signaling.

bioRxiv · Jun 13, 2019Biochemistry