Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption
C. Zhang, Z. Hu, A. G. Lone, M. Artami, M. Edwards, C. C. Zouboulis, M. Stein, T. A. Harris-Tryon
This study identifies SPRR1 and SPRR2 as antimicrobial proteins produced by sebocytes that defend the skin by disrupting bacterial membranes, showing increased susceptibility to infections in their absence.
bioRxiv · Sep 1, 2021Immunology