M. Edwards

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

A conserved pressure-driven mechanism for regulating cytosolic osmolarity

The paper identifies a conserved pressure-driven mechanism for osmoregulation using contractile vacuoles in three distantly related eukaryotic species.

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.

Polymer brush bilayers under stationary shear motion at linear response regime: A theoretical approach

This paper uses statistical mechanics to show that polymer brush bilayers under shear motion exhibit friction due to system structure, not interpenetration, and behaves like Newtonian fluids at small shear rates.

Asymmetric Ion Mobility and Interface Displacement Drive the Signal Enhancement in a Polymer-electrolyte Nanopore

This study investigates how adding PEG to the external solution enhances nanopore signal detection by altering ion transport and interface displacement.

Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

This study identifies SPRR1 and SPRR2 as antimicrobial proteins produced by sebocytes that defend the skin by disrupting bacterial membranes, showing increased susceptibility to infections in their absence.

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

This paper develops synthetic protein nanoparticles delivering a CXCR4 inhibitor to treat glioma by enhancing immunotherapy and reducing tumor progression.

Cancer blues? A validated judgment bias task suggests pessimism in nude mice with tumors

This paper validates a judgment bias task in mice and shows tumor-bearing nude mice exhibit pessimism in response to ambiguous cues.

Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.

Inhibition of 2-Hydroxyglutrate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity

This study shows that inhibiting 2-hydroxyglutarate in mIDH1 gliomas with ATRX/TP53 inactivation improves survival and induces anti-tumor immunity through immunological memory and reduced T-cell exhaustion.

Marine deforestation leads to widespread loss of ecosystem function

The paper shows that marine deforestation in the Aleutian Archipelago reduces biodiversity and primary productivity across 1000 km of coastline.

Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma

This paper tests an immune-stimulatory gene therapy in a mouse model of DIPG, showing increased survival and anti-tumor immunity through adenoviral delivery of TK and Flt3L.

Interpenetration between a polymer brush and a polymerstar at thermal equilibrium: A theoretical approach

The paper uses density functional theory to study polymer star-brush interpenetration, finding repulsion, fluctuating regions, and collapse under interpenetration.

IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.