Author

A. H. Coles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Biscans· 1 shared A. Khvorova· 1 shared B. M. D. C. Godinho· 1 shared D. Echeverria· 1 shared L. Roux· 1 shared M. F. Osborn· 1 shared M. Nikan· 1 shared M. R. Hassler· 1 shared

Activity by Year

2018-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Biscans

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1 paper

Recent·Most cited

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

M. F. Osborn, A. H. Coles, A. Biscans, R. A. Haraszti, L. Roux, S. Davis, S. Ly, D. Echeverria, M. R. Hassler, B. M. D. C. Godinho, M. Nikan, A. Khvorova

This study shows that lipid conjugation affects siRNA hydrophobicity, influencing its distribution via lipoprotein pathways and enabling tissue-specific mRNA silencing without toxicity.

bioRxiv · Mar 23, 2018Pharmacology & Toxicology