Author

A. Biscans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Khvorova· 2 shared D. Echeverria· 2 shared A. Coles· 1 shared A. H. Coles· 1 shared B. M. D. C. Godinho· 1 shared L. Roux· 1 shared M. F. Osborn· 1 shared M. Hassler· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. Khvorova

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2 papers

Recent·Most cited

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

A. Biscans, A. Coles, R. Haraszti, D. Echeverria, M. Hassler, M. Osborn, A. Khvorova

This study develops lipophilic conjugates to enable siRNA delivery to extra-hepatic tissues, showing effective gene silencing in multiple organs.

bioRxiv · Mar 26, 2018Biochemistry

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

M. F. Osborn, A. H. Coles, A. Biscans, R. A. Haraszti, L. Roux, S. Davis, S. Ly, D. Echeverria, M. R. Hassler, B. M. D. C. Godinho, M. Nikan, A. Khvorova

This study shows that lipid conjugation affects siRNA hydrophobicity, influencing its distribution via lipoprotein pathways and enabling tissue-specific mRNA silencing without toxicity.

bioRxiv · Mar 23, 2018Pharmacology & Toxicology