Author

M. R. Hassler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

A. Khvorova· 2 shared D. Echeverria· 2 shared A. Biscans· 1 shared A. H. Coles· 1 shared A. J. Debacker· 1 shared A. Mir· 1 shared A. Tiefenbacher· 1 shared B. H. Ramsahoye· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

A. Khvorova

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis

E. Redl, R. Sheibani-Tezerji, P. Hamminger, G. Timelthaler, M. R. Hassler, S. Lagger, T. Dillinger, L. Hofbauer, M. Zrimsek, A. Tiefenbacher, M. Kothmayer, C. H. Dietz, B. H. Ramsahoye, L. Kenner, C. Bock, , G. Egger

This study shows that DNMT1 is essential for maintaining tumor-specific methylation during NPM-ALK driven T cell lymphomagenesis, despite oncogenic signaling.

bioRxiv · Apr 9, 2020 · PreprintCancer Biology

Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing

A. Mir, J. F. Alterman, M. R. Hassler, A. J. Debacker, E. Hudgens, D. Echeverria, M. H. Brodsky, A. Khvorova, J. K. Watts, E. J. Sontheimer

This study identifies heavily and fully modified crRNA and tracrRNA that enhance Cas9-mediated genome editing efficiency and stability in human cells.

bioRxiv · Mar 28, 2018Biochemistry

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

M. F. Osborn, A. H. Coles, A. Biscans, R. A. Haraszti, L. Roux, S. Davis, S. Ly, D. Echeverria, M. R. Hassler, B. M. D. C. Godinho, M. Nikan, A. Khvorova

This study shows that lipid conjugation affects siRNA hydrophobicity, influencing its distribution via lipoprotein pathways and enabling tissue-specific mRNA silencing without toxicity.

bioRxiv · Mar 23, 2018Pharmacology & Toxicology