Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening
P. W. Kang, A. M. Westerlund, J. Shi, K. McFarland White, A. K. Dou, A. H. Cui, J. R. Silva, L. Delemotte, J. Cui
The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.
Science Advances · Dec 11, 2020Peer-reviewedBiophysics