Author

P. W. Kang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Cui· 4 shared J. Shi· 3 shared A. K. Dou· 2 shared J. R. Silva· 2 shared M. A. Zaydman· 2 shared P. Hou· 2 shared A. Bedi· 1 shared A. Deyawe Kongmeneck· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiophysics

J. Cui

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4 papers

Recent·Most cited

Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function

P. w. Kang, L. Woodbury, P. Angsutararux, N. Sambare, J. Shi, M. Marras, C. Abella, A. Bedi, D. Zinn, J. Cui, J. R. Silva

This study investigates how arrhythmia-associated calmodulin variants affect KCNQ1 binding, membrane trafficking, and function, revealing variable impacts on cardiac ion channel regulation.

bioRxiv · Jan 28, 2023Biophysics

Principles of sensor-effector organization in six-transmembrane ion channels

A. K. Dou, P. W. Kang, P. Hou, M. A. Zaydman, J. Zheng, T. Jegla, J. Cui

The paper uses statistical coupling analysis to study sensor-effector organization in TRP and Kv ion channels, identifying conserved core sectors and family-specific accessory sectors with three localization principles.

bioRxiv · Aug 3, 2021 · PreprintBiophysics

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

P. W. Kang, A. M. Westerlund, J. Shi, K. McFarland White, A. K. Dou, A. H. Cui, J. R. Silva, L. Delemotte, J. Cui

The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.

Science Advances · Dec 11, 2020Peer-reviewedBiophysics

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

bioRxiv · Oct 9, 2019Biophysics