Author

A. M. Westerlund

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

L. Delemotte· 3 shared A. Andersson· 1 shared A. H. Cui· 1 shared A. K. Dou· 1 shared A. Sridhar· 1 shared A.-Y. Bodnar· 1 shared J. Cui· 1 shared J. R. Silva· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

L. Delemotte

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Author profile →

3 papers

Recent·Most cited

Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin

A. M. Westerlund, A. Sridhar, L. Dahl, A. Andersson, A.-Y. Bodnar, L. Delemotte

This paper uses Markov state modeling and molecular dynamics simulations to analyze how the drug TFP inhibits CaM by stabilizing different conformations, revealing three distinct binding modes and their effects on CaM structure.

bioRxiv · Jun 8, 2022Biophysics

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

P. W. Kang, A. M. Westerlund, J. Shi, K. McFarland White, A. K. Dou, A. H. Cui, J. R. Silva, L. Delemotte, J. Cui

The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.

Science Advances · Dec 11, 2020Peer-reviewedBiophysics

Network analysis reveals how lipids and other cofactors influence membrane protein allostery

A. M. Westerlund, O. Fleetwood, S. Perez-Conesa, L. Delemotte

The paper extends residue interaction networks to include lipids and small molecules, showing their role in membrane protein allostery using three protein examples.

The Journal of Chemical Physics · Oct 14, 2020Peer-reviewedBiophysics