Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence
A. H. Khan, R. J. Patel, M. P. Viana, S. M. Rafelski, A. I. Brown, B. M. Zid, T. Tsuboi
This study shows that mitochondrial fragmentation increases protein expression noise due to stochastic co-translational targeting, and that fission-fusion processes reduce this heterogeneity.
bioRxiv · Dec 3, 2023Cell Biology