Author

T. Tsuboi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Takashima· 3 shared I. Mueller· 3 shared J. Healer· 3 shared J. Sattabongkot· 3 shared M. Harbers· 3 shared W.-H. Tham· 3 shared B. M. Zid· 2 shared C. E. Chitnis· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

E. Takashima

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence

A. H. Khan, R. J. Patel, M. P. Viana, S. M. Rafelski, A. I. Brown, B. M. Zid, T. Tsuboi

This study shows that mitochondrial fragmentation increases protein expression noise due to stochastic co-translational targeting, and that fission-fusion processes reduce this heterogeneity.

bioRxiv · Dec 3, 2023Cell Biology

Exocytotic dynamics of glucagon-like peptide-1 from enteroendocrine L cell line is regulated by actin polymerization

K. Harada, M. Takashima, T. Kitaguchi, T. TSUBOI

The paper investigates how actin polymerization regulates exocytosis of GLP-1 granules in mouse L cells after Ca2+ or cAMP elevation.

bioRxiv · Sep 14, 2022 · PreprintCell Biology

Single chain models illustrate the 3D RNA folding shape during translation

T. Guo, O. L. Modi, J. Hirano, H. V. Guzman, T. Tsuboi

The paper develops a simulation method to model 3D RNA folding during translation, showing that single-chain polymer characteristics, not base-pairing, mainly influence mRNA conformation.

bioRxiv · Nov 25, 2021Biophysics

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Z. S.-J. Liu, J. Sattabongkot, M. White, S. Chotirat, C. Kumpitak, E. Takashima, M. Harbers, W.-H. Tham, J. Healer, C. E. Chitnis, T. Tsuboi, I. Mueller, R. J. Longley

This study tracks antibody kinetics against Plasmodium vivax antigens in individuals from a low-transmission region, showing long-lived IgG responses and IgM variability.

bioRxiv · Oct 21, 2021Microbiology

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens in a multiplexed bead-based assay using Luminex(R) technology (Bio-Plex(R)200 or MAGPIX(R))

R. Mazhari, J. Brewster, R. Fong, C. Bourke, Z. S. Liu, E. Takashima, T. Tsuboi, W.-H. Tham, M. Harbers, C. Chitnis, J. Healer, M. Ome-Kaius, J. Sattabongkot, J. Kazura, L. Robinson, , R. Longley

This study compares non-magnetic and magnetic beads for measuring IgG antibodies against P. vivax antigens using Luminex technology across different instruments, finding strong correlations but noting higher protein requirements for magnetic beads.

bioRxiv · Aug 10, 2020Immunology

Mitochondrial volume fraction and translation speed impact mRNA localization and production of nuclear-encoded mitochondrial proteins

T. Tsuboi, M. P. Viana, F. Xu, J. Yu, R. Chanchani, X. G. Arceo, E. Tutucci, J. Choi, Y. S. Chen, R. H. Singer, S. M. Rafelski, B. M. Zid

bioRxiv · Oct 10, 2019Cell Biology

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

J.-A. Chan, D. Wetzel, L. Reiling, K. Miura, D. R. Drew, P. R. Gilson, D. A. Anderson, J. S. Richards, C. A. Long, M. Suckow, V. Jenzelewski, T. Tsuboi, M. J. Boyle, M. Piontek, J. G. Beeson

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.

bioRxiv · Aug 5, 2019Immunology

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

R. J. Longley, M. T. White, E. Takashima, J. Brewster, M. Morita, M. Harbers, L. J. Robinson, F. Matsuura, S.-J. Liu, C. S. N. Li-Wai-Suen, W.-H. Tham, J. Healer, C. Huon, C. E. Chitnis, W. Nguitragool, , I. Mueller

The paper identifies and validates a panel of 8 P. vivax proteins whose IgG antibody responses can detect recent exposure to P. vivax infections within the prior 9 months with 80% sensitivity and specificity.

bioRxiv · Nov 30, 2018 · PreprintMicrobiology