A. I. Brown

Mitochondrial network branching enables rapid protein spread with slower mitochondrial dynamics

The paper models how mitochondrial network structure and dynamics affect protein spread, finding that branching networks enable faster spread with slower dynamics.

Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence

This study shows that mitochondrial fragmentation increases protein expression noise due to stochastic co-translational targeting, and that fission-fusion processes reduce this heterogeneity.

Quantitative modeling of EGF receptor ligand discrimination via internalization proofreading

This study develops quantitative models to show how spatial and kinetic proofreading mechanisms enhance EGFR internalization based on ligand type.

Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling

This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.

Mitochondrial mRNA localization is governed by translation kinetics and spatial transport

The paper develops a model to explain how mitochondrial mRNA localization in yeast depends on translation kinetics and spatial transport, finding that metabolic state influences localization through changes in these factors.

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.