Author

A. Herring-Nicholas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:perturbation response prediction· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:software / tool· 1

Frequent Co-Authors

E. A. Josephs· 2 shared H. Dimig· 1 shared M. Roesing· 1 shared T. Supakar· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBioengineering

E. A. Josephs

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2 papers

Recent·Most cited

Compartmentalized CRISPR Reactions (CCR) for High-Throughput Screening of Guide RNA Potency and Specificity

T. Supakar, A. Herring-Nicholas, E. A. Josephs

This paper introduces CCR, a method to screen gRNA potency and specificity in vitro by confining CRISPR reactions in microemulsions, enabling high-throughput validation of large gRNA variant libraries.

bioRxiv · May 7, 2024Bioengineering

Selection of Extended CRISPR RNAs with Enhanced Targeting and Specificity

A. Herring-Nicholas, H. Dimig, M. Roesing, E. A. Josephs

The paper presents a method to screen CRISPR gRNA variants with 5-nucleotide extensions to enhance Cas9 specificity for target sites while reducing off-target activity.

bioRxiv · Jan 11, 2023Bioengineering