Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems
R. J. Harding, P. Loppnau, S. Ackloo, A. Lemak, A. Hutchinson, B. Hunt, A. Holehouse, J. Ho, L. Fan, L. Toledo-Sherman, A. Seitova, C. Arrowsmith
This paper develops a toolkit for producing mutant and wild-type huntingtin proteins in eukaryotic systems to enable biochemical and structural studies of HD-related mutations.
bioRxiv · Feb 5, 2019Biochemistry