Author

A. Lemak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Hutchinson· 2 shared A. Seitova· 2 shared C. H. Arrowsmith· 2 shared L. Fan· 2 shared P. Loppnau· 2 shared R. J. Harding· 2 shared A. Ahlner· 1 shared A. Holehouse· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

A. Hutchinson

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Author profile →

3 papers

Recent·Most cited

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

Y. Wei, A. Ahlner, C. Redel, A. Lemak, I. Johansson-Akhe, S. Houliston, T. M. G. Kenney, A. Tamachi, V. Morad, S. Duan, D. W. Andrews, B. Wallner, M. Sunnerhagen, C. H. Arrowsmith, L. Z. Penn

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

bioRxiv · Dec 2, 2021Cancer Biology

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

bioRxiv · Apr 2, 2021Biochemistry

Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

R. J. Harding, P. Loppnau, S. Ackloo, A. Lemak, A. Hutchinson, B. Hunt, A. Holehouse, J. Ho, L. Fan, L. Toledo-Sherman, A. Seitova, C. Arrowsmith

This paper develops a toolkit for producing mutant and wild-type huntingtin proteins in eukaryotic systems to enable biochemical and structural studies of HD-related mutations.

bioRxiv · Feb 5, 2019Biochemistry