Author

A. J. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C.-A. Malinczak· 2 shared R. Peterson· 2 shared X. Lu· 2 shared A. Han· 1 shared A. Takakura· 1 shared B. Breen· 1 shared B. Ferraro· 1 shared B. Hellner· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPharmacology & Toxicology

C.-A. Malinczak

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dose range-finding toxicity study in rats with recombinant human lactoferrin produced in Komagataella phaffii

R. Peterson, R. B. Crawford, L. K. Blevins, N. E. Kaminski, J. S. Sass, B. Ferraro, R. Vishwanath-Deutsch, A. J. Clark, C.-A. Malinczak

This study evaluates the oral toxicity of recombinant human lactoferrin in rats at various doses, finding it well-tolerated up to 2000 mg/kg/day.

bioRxiv · Jan 22, 2024Pharmacology & Toxicology

Evaluation of the potential food allergy risks of recombinant human lactoferrin expressed in Komagataella phaffii

Y. Anaya, R. Rosario Martinez, R. E. Goodman, P. Johnson, S. Vajpeyi, X. Lu, R. Peterson, S. M. Weyers, B. Breen, K. Newsham, B. Scottoline, A. J. Clark, C.-A. Malinczak

The paper assesses the allergenic risk of recombinant human lactoferrin produced in Komagataella phaffii using bioinformatics, glycan analysis, and simulated digestion, finding low allergenic potential.

bioRxiv · Jan 18, 2024 · PreprintImmunology

Characterization of Recombinant Human Lactoferrin Expressed in Komagataella Phaffii

X. Lu, C. Cummings, U. A. Osuala, N. H. Yennawar, K. E. W. Namitz, B. Hellner, P. B. Besada-Lombana, R. D. Peterson, A. J. Clark

This study characterizes recombinant human lactoferrin produced in yeast, confirming its sequence, purity, glycosylation, structure, and thermal stability similar to native human milk lactoferrin.

bioRxiv · Jan 9, 2024 · PreprintBiophysics

HNF4α mediated QPRT expression in the kidney facilitates resilience against acute kidney injury

A. J. Clark, M. C. Saade, V. Vemireddy, K. Q. Vu, B. M. Flores, V. Etzrodt, E. J. Ciampa, H. J. Huang, A. Takakura, K. Zandi-Nejad, Z. K. Zsengeller, S. M. Parikh

This study identifies HNF4α regulation of QPRT expression in the kidney as a mechanism enhancing resilience against acute kidney injury.

bioRxiv · May 23, 2023Physiology

Shiitake mycelium fermentation improves digestibility, nutritional value, flavor and functionality of plant proteins

M. Nadal, A. J. Clark, B. Soni, B. Sharkey, T. Acree, E. Lavin, H. Bailey, H. Stein, A. Han, M. Elie

This study shows that fermenting pea and rice protein with shiitake mycelium improves digestibility, nutritional value, and flavor, making it a better meat substitute.

bioRxiv · Oct 7, 2021Bioengineering