A. J. Costa-Filho

This study investigates how liquid-liquid phase separation facilitates the formation of a vesicular-like compartment for unconventional protein secretion in yeast under starvation stress.

This study constructs a chimera protein that forms biomolecular condensates with enzymatic activity for degrading polycyclic aromatic hydrocarbons.

This study reconstructs ancestor GRASP proteins to investigate their evolution and role in Golgi ribbon formation and stress-induced secretion.

This study investigates how myristoylation affects GRASP55's membrane anchoring and structural properties using biophysical and computational methods.

This study presents the first high-resolution structure of the GOLD domain of TMED1 and its biophysical properties, revealing dimer formation and insights into its membrane orientation.

This study detects amyloid-like fibrils in vivo using autofluorescence from β-sheets, showing Grh1's role in stress responses without extrinsic probes.

This study examines how nicotine affects the thermodynamics of DPPC lipid membrane phase coexistence using calorimetry, EPR, and NLLS simulations.

This paper investigates the structural flexibility of GRASP PDZ domains and explains their promiscuous interactome through biophysical analysis.

This study uses molecular dynamics simulations to analyze conformational transitions and free energy profiles of PepTst, revealing how protonation and ligand binding influence the transporter's mechanism.

This study investigates the structural properties of human GRASP55 in solution, revealing its disordered regions, monomeric state, and aggregation behavior during denaturation.

This study compares GRASP proteins from humans and lower eukaryotes to understand differences in Golgi cisternae assembly and evolution.

The paper shows that the yeast GRASP Grh1 is intrinsically disordered and can form amyloid fibrils, suggesting these properties may be common in the GRASP family.