The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader
N. Puri, A. J. Fernandez, V. L. O'Shea Murray, S. McMillan, J. L. Keck, J. M. Berger
This study investigates how ATPase elements in E. coli DnaC regulate helicase loading and DNA unwinding, identifying a new element called the arginine-coupler that prevents futile ATP cycling.
bioRxiv · Oct 21, 2020Biochemistry